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Measures

Number of red blood cells in the blood

Identifies

Red blood cell disorders

Measures: Number of red blood cells in the blood

Identifies: Red blood cell disorders

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What is the maximum days the report can be obtained for the test

The maximum days the report can be obtained for the test IGH/BCL2 t(14;18) Follicular Lymphoma Test By FISH is typically within 7-10 business days.

What are the prerequisites for the test IGH/BCL2 t(14;18) Follicular Lymphoma Test By FISH

  • Peripheral blood or bone marrow specimen
  • Formalin-fixed, paraffin-embedded tissue block or slide
  • Specimen must be received within 72 hours of collection
  • Requisition form with patient information and clinical history

What are the measure values for the test IGH/BCL2 t(14;18) Follicular Lymphoma Test By FISH

  • Positive: Presence of IGH/BCL2 translocation t(14;18)
  • Negative: Absence of IGH/BCL2 translocation t(14;18)
  • Indeterminate: Inconclusive result, further testing may be required

What does this test IGH/BCL2 t(14;18) Follicular Lymphoma Test By FISH identify?

IGH/BCL2 t(14;18) Follicular Lymphoma Test By FISH

This test identifies the translocation between the IGH (immunoglobulin heavy chain) gene on chromosome 14 and the BCL2 (B-cell lymphoma 2) gene on chromosome 18. This translocation is commonly found in follicular lymphoma, a type of non-Hodgkin lymphoma.

Fluorescence in situ hybridization (FISH) is a molecular technique used to detect specific DNA sequences in chromosomes. In this test, FISH is used to identify the t(14;18) translocation, which results in the overexpression of the BCL2 gene. This overexpression is a key feature of follicular lymphoma and plays a role in the development and progression of the disease.

Why is this test IGH/BCL2 t(14;18) Follicular Lymphoma Test By FISH taken?

IGH/BCL2 t(14;18) Follicular Lymphoma Test By FISH

This test is taken to detect the presence of a specific chromosomal abnormality known as t(14;18) in patients suspected of having follicular lymphoma. This translocation involves a fusion of the IGH gene on chromosome 14 with the BCL2 gene on chromosome 18, resulting in overexpression of the anti-apoptotic BCL2 protein. This abnormality is found in the majority of cases of follicular lymphoma.

By using Fluorescence In Situ Hybridization (FISH) technology, this test can identify the t(14;18) translocation in a patient's cells, helping in the diagnosis and management of follicular lymphoma. It can also provide information on the prognosis of the disease and guide treatment decisions.

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